Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

时间使用流行病学在身体活动研究领域的应用     

宋俊辰  李红娟  王政淞 《体育科学》2020,(1):79-88

身体活动与健康促进是公共卫生及运动科学领域研究的重点方向之一。个体一日24 h由睡眠、久坐及各种强度的身体活动组成,已有研究多从单一维度探讨这些行为对健康的影响,忽视了身体活动、久坐、睡眠等行为之间的内在联系及对健康结果的综合影响,可能使相应行为与健康效应间的关联产生偏差。时间使用流行病学研究方法的引入克服了这一不足。以“时间分配”作为切入点,综述国际学术界关于身体活动、久坐和睡眠行为对健康影响的研究现状,并系统阐述了等时替代研究方法、活动-平衡模型、时间使用流行病学的发展及其研究框架。基于此,展望了时间使用流行病学相关理论在身体活动研究领域的应用前景:1、开发新式测量工具并完善数据收集和分析方法;2、建立有关时间使用模式的综合评价体系;3、制订我国大众人群的活动-平衡时间分配推荐指南方案。  相似文献   

An analysis of the reach and effectiveness of distance learning in India during school closures due to COVID-19     

《International Journal of Educational Development》2021

In India, more than 276 million children and youth were out of school for extended periods since March 2020 due to school closures in response to COVID-19. A key challenge has been how to measure the impact of responses to continuity of learning both to ensure more effective responses in the event of further disruptions, but also to help the education community conceptualize more creative and effective approaches to learning, through blended and flexible approaches. This study reflects on the findings from a UNICEF survey targeting parents and adolescents across 6 states in India, and identifies lessons learned for addressing learning inequities during future school closures. We focus on measuring three key variables – access to technology, their utilization, and perceived learning for different profiles of children. As students began learning from home, technology access rates in households were initially used to determine the estimated maximum reach of different distance learning modalities during school closures. Beyond access, we find significant variations in adolescents’ use of technology for learning purposes and their perceptions of learning, linked to the type of remote learning modality, gender, location and type of school. We discuss the implications for government strategies and policies to ensure better utilization of technologies which are available in households and to address equity gaps in learning opportunities.  相似文献   

上海“体教结合”举措下竞技体育后备人才“学生-运动员”双重角色的认同、冲突与转化          下载免费PDF全文

侯爽 《体育科研》2019,(3):30-37

“体教结合”是解决当前我国竞技体育发展问题的重要途径和举措。传统的体育后备人才培养模式只重视专项体育技能的发展而忽视了文化教育的重要性，不利于个体的全面发展。“体教结合”更重视人的全面发展，体育与教育的融合，使得竞技体育人才逐渐从运动员这一单一角色向“学生-运动员”双重角色转变。研究以角色认同为切入口，探讨上海“体教结合”举措下，角色的转变对体育竞技后备人才的影响。选取上海体育学院中国乒乓球学院少年班学员作为“学生-运动员”样本，选取国家乒乓球青年队及部分省市队队员作为职业运动员样本，使用结构化心理测量工具，对比两类受访者在运动与学业上的角色认同、心理倦怠与动机变量的差异。得出：在上海“体教结合”举措下，竞技体育后备人才认同“学生-运动员”双重角色，他们在学业任务中的卷入程度更高；双重角色使运动员在运动任务与学业任务上的主观价值感存在差异，表现出双重角色之间的冲突，但对个体的整体人生规划并不冲突；双重角色之间的转化，对于“学生-运动员”的心理健康存在促进效应。  相似文献   

From objects to subjects: Repositioning teachers as policy actors doing policy work     

《Teaching and Teacher Education》2018

Within policy discourses, teachers are positioned as objects of reform who enact policies under rational systems of observation and accountability and are, therefore, situated as de-professionalized actors lacking expert knowledge. This research project asks relatively straight-forward questions: If practicing teachers were given a voice in political debates over urban education policy and reform, what would they say? What macro-level policy problems would they identify as being important? Findings indicate the primary policy problems include Systemic Inequity and Bad Policy. The primary policy solutions include, Schools as a Community Resource; Shared Decision-Making; Contextual Goals; and Time, Space and Resources.  相似文献   

不同抗阻训练方案对T淋巴细胞亚群迁移和凋亡的影响*     

王焱源 《广州体育学院学报》2019,(3):112-117

研究旨在探讨一次不同抗阻训练方案对外周血CD4＋和CD8＋T淋巴细胞亚群迁移和凋亡的影响。通过实验法15名无训练经历的健康青年男性分别进行一次以促进肌肉肥大（H-RT组，方案：70%1RM，10RM，3组，组间间歇1.5 min）和以改善肌肉耐力（E-RT组，方案：60%1RM，15RM，3组，组间间歇1 min）为目的的抗阻训练方案。并于训练前、训练后即刻、训练后2 h和24 h利用流式细胞仪测定表面标志物CX3CR1和annexin V表达量检测CD4＋、CD8＋T淋巴细胞亚群迁移和凋亡（用阳性表达率表示）。得出以下数据：（1）CD4＋T细胞在H-RT组运动后即刻和运动后24 h，annexin V和CX3CR1阳性表达率显著性升高（P<0.05）。E-RT组annexin V阳性表达率在运动后即刻降低（P<0.05），24 h显著性升高（P<0.05）；CX3CR1阳性表达率仅在运动后即刻升高（P<0.05）。（2）CD8＋T细胞在H-RT组和E-RT组运动后即刻和运动后24 h，annexin V和CX3CR1阳性表达率均显著性升高（P<0.05）。通过对以上数据的分析，研究得出以下结论：CD4＋T淋巴细胞亚群对于急性抗阻训练的免疫反应存在运动方案依赖性。  相似文献   

两种大强度间歇训练对优秀公路自行车运动员有氧能力的影响          下载免费PDF全文

屈成刚  唐一丹 《体育科研》2019,(1):64-71

目的：比较两种大强度间歇训练手段对优秀自行车运动员有氧运动能力的影响。方法：将15名备战全国“十三运”的云南省自行车队男子运动员随机分为3组， S组训练方案采用SIT/耐力训练， H组训练方案采用HIIT/耐力训练， C组为对照组，进行传统耐力性训练；训练持续3周。训练前后进行递增负荷测试和有氧运动能力测试，测试指标包括最大摄氧量绝对值（VO2max）、最大摄氧量相对值（VO2max/kg）、每分通气量（VE）、最大心率（HRmax），并通过公式计算每搏输出量（SV），以及测试递增负荷后即刻血乳酸（BLA）、最大有氧功率（P）和40 km个人计时成绩进行了测试。结果：（1）3周训练后，S组运动员VE、HRmax、SV、VO2max、VO2max/kg、P和ITT40km均较训练前有显著性提高（P＜0.05）；H组运动员VE、VO2max/kg、ITT40km较训练前有显著性增加（P＜0.05），BLA有显著性的下降（P＜0.05）。（2）S组运动员ΔVE、ΔHRmax、ΔSV、ΔVO2max、ΔVO2max/kg、ΔBLA、ΔITT40km显著提升（P＜0.05），且优于其余两组；H组仅ΔITT40km存在明显提升（P＜0.05）。结论：间歇训练结合耐力训练对优秀公路自行车运动员的呼吸系统、有氧供能系统可产生积极的影响；而且，SIT结合耐力训练较HIIT结合耐力训练或传统耐力训练更能提高公路自行车运动员的有氧代谢能力和有氧运动能力，训练效果更佳。  相似文献   

Promoting a participatory convergence in a Spanish context: an inter-university action research project using visual narrative     

Elia Fernández-Díaz  Carlos Rodríguez-Hoyos  Adelina Calvo Salvador  Gloria Braga Blanco  Lorea Fernández-Olaskoaga  Prudencia Gutiérrez-Esteban 《Educational Action Research》2019,27(3):362-378

ABSTRACT

This article focuses on the deconstruction of an inter-university action research project that has allowed us to rethink our teaching and research, questioning the social, political and ethical dimensions of the university. Following the pre-assembly proposal to promote participatory convergence, organized within the framework of the 1^st Global Assembly for Knowledge Democracy (2017), an action research process was implemented in order to generate systematic inquiry around the current situation of the university and the need to act and rethink our commitment to promoting changes in this context. We have reflected on the meaning of democratization, rethinking the pedagogical relationship with our students and how we critically commit them to promote activism. We generated an environment where we look for the meaning of our practices by means of a visual narrative which has enabled us to weave and identify our own biography and become aware of where we are and why we act in one way or another. We have also focused on the search for the meaning of our actions in relation to the community we belong to and how to deal with the challenges of social justice, encouraging collaboration with other networks in a wider inter-university framework.  相似文献   

Quality flaw prediction in Spanish Wikipedia: A case of study with verifiability flaws     

Edgardo Ferretti  Leticia Cagnina  Viviana Paiz  Sebastián Delle Donne  Rodrigo Zacagnini  Marcelo Errecalde 《Information processing & management》2018,54(6):1169-1181

In this work, we present the first quality flaw prediction study for articles containing the two most frequent verifiability flaws in Spanish Wikipedia: articles which do not cite any references or sources at all (denominated Unreferenced) and articles that need additional citations for verification (so-called Refimprove). Based on the underlying characteristics of each flaw, different state-of-the-art approaches were evaluated. For articles not citing any references, a well-established rule-based approach was evaluated and interesting findings show that some of them suffer from Refimprove flaw instead. Likewise, for articles that need additional citations for verification, the well-known PU learning and one-class classification approaches were evaluated. Besides, new methods were compared and a new feature was also proposed to model this latter flaw. The results showed that new methods such as under-bagged decision trees with sum or majority voting rules, biased-SVM, and centroid-based balanced SVM, perform best in comparison with the ones previously published.  相似文献